ARCTIC-3D: all you want to know about protein-specific interfaces
ARCTIC-3D is a software for data-mining and clustering of protein interface information. It allows you to retrieve all the existing interface information for your desired protein from the PDBE graph database, grouping similar interfaces in interacting surfaces.
The software first checks your input (a uniprot ID, a FASTA file, or a PDB file), and then retrieves the existing interaction data from the graph API. Such interfaces are projected on a selected PDB structure and their dissimilarity is calculated, thus allowing for the application of a hierarchical clustering algorithm.
In output you will see how your favourite protein can display different binding surfaces, each one characterised by few residues that are always present (hotspots) and other amino acids which are at the interface only from time to time.
