DisVis Webserver

Welcome to the Utrecht Biomolecular Interaction Web Portal >>

DisVis visualizes the accessible interaction space!

DisVis allows you to visualize and quantify the information content of distance restraints between macromolecular complexes.
It performs a full and systematic 6 dimensional search of the three translational and rotational degrees of freedom to determine the number of complexes consistent with the restraints. In addition, it outputs the percentage of restraints being violated and a density that represents the center-of-mass position of the scanning chain corresponding to the highest number of consistent restraints at every position in space.

In order to constantly improve our service and give you the best experience, we would really appreciate if you could take the time to complete our short online survey (~5min) available here: https://goo.gl/MYBt9R

DisVis webserver

REGISTRATION: To use the DisVis server you must have registered for an account. If you do not have an account yet you can register here

Submit your job to:

DISVIS server

Runtimes

Average run time in minutes (5 runs each, excluding pre- and post-processing, and queued time) for runs submitted to the local CPU and grid GPGPU resources via the DisVis web server. Analysis was performed with the RNA polymerase II complex of S. cerevisiae.

DisVis Webinar

Watch the 11th BioExcel Webinar on “Robust solutions for cryoEM fitting and visualisation of interaction space”. This Webinar presented by the Disvis team features a comprehensive overview about the general methodology and algorithms behind DisVis. Furthermore it provides a quick introduction to the DisVis web portal implementation including a live demo of the portal.

Reference for use of the server

When using the DisVis server please cite:

R.V. Honorato, P.I. Koukos, B. Jimenez-Garcia, A. Tsaregorodtsev, M. Verlato, A. Giachetti, A. Rosato and A.M.J.J. Bonvin (2021). Structural biology in the clouds: The WeNMR-EOSC Ecosystem. Frontiers Mol. Biosci., 8, fmolb.2021.729513.
G.C.P. van Zundert, M. Trellet, J. Schaarschmidt, Z. Kurkcuoglu, M. David, M. Verlato, A. Rosato and A.M.J.J. Bonvin (2016) The DisVis and PowerFit web servers: Explorative and Integrative Modeling of Biomolecular Complexes.
J. Mol. Biol., Advanced Online Publication.
G.C.P. van Zundert and A.M.J.J. Bonvin (2015) DisVis: Quantifying and visualizing accessible interaction space of distance-restrained biomolecular complexes." Bioinformatics 31, 3222-3224.

and add the following acknowledgment:

The FP7 WeNMR (project# 261572), H2020 West-Life (project# 675858), the EOSC-hub (project# 777536) and the EGI-ACE (project# 101017567) European e-Infrastructure projects are acknowledged for the use of their web portals, which make use of the EGI infrastructure with the dedicated support of CESNET-MCC, INFN-LNL-2, NCG-INGRID-PT, TW-NCHC, CESGA, IFCA-LCG2, UA-BITP, TR-FC1-ULAKBIM, CSTCLOUD-EGI, IN2P3-CPPM, CIRMMP, SURFsara and NIKHEF, and the additional support of the national GRID Initiatives of Belgium, France, Italy, Germany, the Netherlands, Poland, Portugal, Spain, UK, Taiwan and the US Open Science Grid.

Disvis software

You can also install DisVis directly on your computer. Source code is available under Apache 2.0 license here: Github::DisVis

Powered by: This work is co-funded by the Horizon 2020 projects EOSC-hub and EGI-ACE (grant numbers 777536 and 101017567), BioExcel (grant numbers 823830, 675728 and 101093290)
and by a computing grant from NWO-ENW (project number 2019.053).